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Year : 2022  |  Volume : 8  |  Issue : 2  |  Page : 171-173

Secondary Amyloidosis with Fatal Outcome in a Child with Meningomyelocele: Need for a Closer Renal Surveillance

1 Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India
2 Department of Pathology, GB Pant Institute of Postgraduate Education and Research, New Delhi, India

Correspondence Address:
Aashima Dabas
Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi 110002
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mamcjms.mamcjms_60_21

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Amyloidosis constitutes a group of diseases characterized by extracellular deposition of fibrils composed of low molecular weight subunits of a variety of proteins. Secondary amyloidosis may result from chronic inflammatory conditions such as familial Mediterranean fever, juvenile idiopathic arthritis, tuberculosis, and bronchiectasis. Myelomeningocele is reported rarely in literature as a cause of amyloidosis. We report here a case of 6-year-old boy with operated congenital lumbar myelomeningocele with paraparesis and neurogenic bladder, who was diagnosed with nephrotic syndrome with hypertension. He underwent a renal biopsy which showed amyloidosis. During the course of treatment, he acquired a perigenital infection and later succumbed to it. A closer follow-up of patients with neurogenic bladder can help identify and manage renal complications early.

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