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ORIGINAL ARTICLE
Year : 2021  |  Volume : 7  |  Issue : 3  |  Page : 211-217

Reporting of Animal Research Studies in Concordance with ARRIVE Guidelines in Indian Medical Journals: A Retrospective Study


1 Department of Pharmacology, Dr Baba Saheb Ambedkar Medical College, New Delhi, India
2 Department of Pharmacology, Maulana Azad Medical College, New Delhi, India
3 Department of Pharmacology, Vardhman Mahavir Medical College, New Delhi, India

Correspondence Address:
Dr. Bhupinder Singh Kalra
Department of Pharmacology, Maulana Azad Medical College, New Delhi-110002
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mamcjms.mamcjms_75_21

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Background: Inappropriate reporting of animal studies has been a serious issue. The Animals in Research: Reporting in Vivo Experiments (ARRIVE) guidelines were published to improve design, analysis, and reporting of animal studies. Methods: The present study is a retrospective observational study of published original research using small laboratory animals. Studies published between the year 2015 and 2020 in Indian Journal of Medical Research (IJMR), Indian Journal of Pharmacology (IJP), Indian Journal of Experimental Biology (IJEB), and Journal of Pharmacology and Pharmacotherapeutics (JPP) were reviewed in accordance with ARRIVE guidelines. Results: Three hundred and seventy-seven studies (JPP n = 15, IJMR n = 37, IJEB n = 157, IJP n = 167) were analyzed. A statement regarding ethics approval was reported in 90.2% of studies. Information regarding randomization and blinding was reported in 20.4% and 0.53% of studies, respectively. Only nine studies mentioned sample-size calculation. Macroenvironmental information such as room temperature/humidity were detailed in 87.5% and light/dark cycle in 96.5% of studies. Concerning microenvironmental conditions, access to food and water was reported in 75% of studies. Only 6.3% studies mentioned the details of adverse events. Information regarding humane endpoint was missing in all studies. Conclusion: Inappropriate and inadequate reporting in some areas of animal research need to be curbed by adhering to ARRIVE guidelines.


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